实际分子量 37kDa 英文名称 Anti-TICAM2 Polyclonal Antibody 靶标 TICAM2 别名 Putative NF-kappa-B-activating protein 502; TCAM2_HUMAN; TICAM-2; TICAM2; TIR containing adapter molecule 2; TIR domain containing adaptor protein; TIR domain-containing adapter molecule 2; TIRAP 3; TIRAP3; TIRAP3a short form; TIRP; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; TRAM; TRIF-related adapter molecule; 宿主 Rabbit 预测交叉反应 Bovine 稀释比例 WB 1:1000-3000. IHC 1:100-300. Gene ID 353376/100302736 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q86XR7 蛋白分子量 27/46kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Cell membrane 免疫原 Recombinant protein of human TICAM2 亚型 IgG 纯化方法 Affinity purification 背景资料 Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction (PubMed:16603631, PubMed:16757566, PubMed:25385819, PubMed:25825441)In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819).Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567).Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606). Public Immunogen Range 1-236aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse 应用 WB IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。