英文名称 Anti-IGHM Polyclonal Antibody 靶标 IGHM 宿主 Rabbit 稀释比例 IHC 1:50-200. Gene ID 3507 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P01871 蛋白分子量 49/52kd 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Cell membrane 免疫原 Recombinant protein of human IGHM 亚型 IgG 纯化方法 Affinity purification 背景资料 IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553). Public Immunogen Range 248-597aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。