英文名称 Anti-SGTA Polyclonal Antibody 靶标 SGTA 别名 Alpha-SGT;UBP;Vpu-binding protein;SGT;SGT1 宿主 Rabbit 预测交叉反应 Bovine 稀释比例 WB 1:1000-3000;IHC 1:100-300. Gene ID 6449 Swiss Prot O43765 保存 Store at -20°C. Avoid freeze / thaw cycles. 蛋白分子量 34kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Nucleus 免疫原 Recombinant protein of human SGTA 亚型 IgG 纯化方法 Affinity purification 背景资料 Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). Public Immunogen Range 1-314aa 克隆类型 Polyclonal Antibody 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。