靶标 PSME4 别名 PA200 ;KIAA0077 ; Proteasome Activator 200 kDa ; Proteasome activator complex subunit 4 ; Proteasome activator PA200 ; PSME 4 ; psme4 ; PSME4_HUMAN 宿主 Rabbit 预测交叉反应 Bovine ;Zebrafish 稀释比例 WB 1:1000-3000. ;IHC 1:50-200. Gene ID 23198 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q14997 蛋白分子量 25/114/140/211kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Cytoplasm Nucleus 免疫原 Recombinant protein of human PSME4 亚型 IgG 纯化方法 Affinity purification 背景资料 Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. Public Immunogen Range 1-20216aa 克隆类型 Polyclonal Antibody 交叉反应 Human ;Mouse ;Rat 应用 WB IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。