靶标 MAPK8IP1 别名 MAPK8IP1;IB1;JIP-1;JIP1;PRKM8IP 宿主 Rabbit 稀释比例 IHC 1:50-200. Gene ID 9479 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q9UQF2 蛋白分子量 78kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Cytoplasm Cell membrane Nucleus 免疫原 A synthetic peptide of human MAPK8IP1 亚型 IgG 纯化方法 Octanoic acid-ammonium sulfate precipitation 背景资料 This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. Public Immunogen Range 175-225/711aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse;Rat 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。