靶标 MDR1 别名 P-Glycoprotein;Multi Drug Resistance Associated Protein;ABCB1;ATP-binding cassette sub-family B (MDR/TAP);member 1;ABC20;CD243;CD243 antigen;CLCS;Multidrug resistance protein 1;P glycoprotein 1;p-GP;gp170; 宿主 Rabbit 稀释比例 WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 Flow-Cyt=1μg/Test ICC=1:100 Gene ID 5243 保存 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Swiss Prot P21447 蛋白分子量 141kDa 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 亚细胞定位 Cell membrane;Multi-pass membrane protein. 免疫原 KLH conjugated synthetic peptide derived from human MDR1 亚型 IgG 纯化方法 Affinity purification 背景资料 P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas. Public Immunogen Range 21-100/1272aa 克隆类型 Polyclonal Antibody 交叉反应 Human Rat Mouse 应用 WB ICC Flow-Cyt ELISA IF IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。