靶标 BCAR3 别名 BCAR 3;BCAR3;BCAR3_HUMAN;Breast cancer anti estrogen resistance 3;Breast cancer anti estrogen resistance protein 3;Breast cancer anti-estrogen resistance protein 3;Breast cancer antiestrogen resistance 3;dJ1033H22.2;dJ1033H22.2 breast cancer anti estrogen resistance 3;dJ1033H22.2 breast cancer antiestrogen resistance 3;KIAA0554;Novel SH2 containing protein 2;Novel SH2-containing protein 2;NSP 2;NSP2;SH2 containing protein Nsp2;SH2 domain containing protein 3B;SH2 domain-containing protein 3B;SH2D3B 宿主 Rabbit 预测交叉反应 Bovine;Monkey 稀释比例 WB 1:5000-8000.;IHC 1:50-200. Gene ID 8412 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot O75815 蛋白分子量 56/82/93kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human BCAR3 亚型 IgG 纯化方法 Affinity purification 背景资料 Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110).Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110).Promotes insulin-mediated membrane ruffling (By similarity).In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031).Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity).May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity).Regulates EGF-induced DNA synthesis (PubMed:18722344).Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity).Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity).Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity).Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity).However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). Public Immunogen Range 40-390aa 克隆类型 Polyclonal Antibody 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。