靶标 SPAG5 别名 Astrin;Deepest;hMAP 126;hMAP126;MAP 126;MAP126;Mitotic spindle associated protein;Mitotic spindle associated protein p126;Mitotic spindle coiled coil related protein;Mitotic spindle-associated protein p126;SPAG 5;SPAG5;SPAG5_HUMAN;Sperm associated antigen 5;Sperm tail protein Spag 5;Sperm tail protein Spag5;Sperm-associated antigen 5 宿主 Rabbit 稀释比例 IHC 1:25-100. Gene ID 10615 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q96R06 蛋白分子量 134kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Cytoplasm Nucleus 免疫原 Recombinant protein of human SPAG5 亚型 IgG 纯化方法 Affinity purification 背景资料 Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074).Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074).In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792).Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116).May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). Public Immunogen Range 10-360aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。