靶标 MMP13 别名 CLG 3;CLG3;Collagenase 3;Collagenase3;MANDP1;Matrix metallopeptidase 13 (collagenase 3);Matrix Metalloproteinase 13;Matrix metalloproteinase-13;MMP 13;MMP-13;Mmp13;MMP13_HUMAN;EC 3.4.24.22;EC 3.4.24.24;EC 3.4.24.35;EC 3.4.24.65;EC 3.4.24.7 宿主 Rabbit 预测交叉反应 Bovine;Horse;Rabbit 稀释比例 IHC 1:100-300. Gene ID 4322 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P45452 蛋白分子量 54kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Secreted 免疫原 Recombinant protein of human MMP13 亚型 IgG 纯化方法 Affinity purification 背景资料 Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. Public Immunogen Range 1-350aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse;Rat 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。