靶标 USP13 别名 Isopeptidase T3;ISOT 3;ISOT-3;ISOT3 宿主 Rabbit 预测交叉反应 Cow;Chicken 稀释比例 WB 1:1000-3000. Gene ID 8975 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q92995 蛋白分子量 90/97kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Cytoplasm Nucleus 免疫原 A synthetic peptide of human USP13 亚型 IgG 纯化方法 Affinity purification 背景资料 Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data. Public Immunogen Range 145-195/863aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse 应用 WB 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。