靶标 TIMELESS 别名 FLJ12640;FLJ20714;hTIM;Protein timeless homolog;TIM;TIM_HUMAN;TIM1;Timeless;timeless circadian clock 1;timeless circadian clock;timeless homolog;TIMELESS1;Tof1 homolog;timeless homolog (Drosophila);hTIMTIMELESS1 宿主 Rabbit 稀释比例 WB 1:1000-3000. Gene ID 8914 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q9UNS1 蛋白分子量 139kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Nucleus 免疫原 Recombinant protein of human TIMELESS 亚型 IgG 纯化方法 Affinity purification 背景资料 Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:9856465, PubMed:17141802, PubMed:17296725, PubMed:23418588, PubMed:26344098).Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725).TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725).Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214).In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214).May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197).Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588).Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:9856465).May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). Public Immunogen Range 859-1209aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse;Rat 应用 WB 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。