靶标 BABAM2 别名 brain and reproductive organ-expressed (TNFRSF1A modulator);BRCA1/BRCA2-containing complex subunit 45;subunit 4;BRISC and BRCA1-A complex member 2;BRCA1-A complex subunit BRE;BRCA1/BRCA2-containing complex subunit 45;Brain and reproductive organ-expressed protein;BRCC45;BRE 宿主 Rabbit 稀释比例 WB 1:1000-3000.;IHC 1:50-200. Gene ID 9577 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q9NXR7 蛋白分子量 43/44/47kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Cytoplasm Nucleus 免疫原 Recombinant protein of human BABAM2 亚型 IgG 纯化方法 Octanoic acid-ammonium sulfate precipitation 背景资料 Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748).In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748).Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665).Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113).The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665).The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985).Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:15465831). Public Immunogen Range 1-383aa 克隆类型 Polyclonal Antibody 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。