靶标 BRCA1 别名 BRCA 1;BRCA1;BRCA1 DNA repair associated;BRCA1/BRCA2 containing complex subunit 1;BRCA1/BRCA2-containing complex, subunit 1;BRCA1_HUMAN;BRCAI;BRCC 1;BRCC1;Breast and ovarian cancer susceptibility protein 1;Breast Cancer 1;Breast Cancer 1 Early Onset;Breast cancer type 1 susceptibility protein;BROVCA1;FANCS;IRIS;PNCA4;PPP1R53;Protein phosphatase 1 regulatory subunit 53;PSCP;RING finger protein 53;RNF53 宿主 Rabbit 预测交叉反应 Bovine;A.thaliana;Chimpanzee;Dog 稀释比例 IHC 1:50-200. Gene ID 672 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P38398 蛋白分子量 7/78/81/85/202/206/208/210kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Cytoplasm Nucleus Cell membrane 免疫原 Recombinant protein of human BRCA1 亚型 IgG 纯化方法 Affinity purification 背景资料 E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:12887909, PubMed:10500182, PubMed:19261748).It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688).The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172).Regulates centrosomal microtubule nucleation (PubMed:18056443).Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:12183412, PubMed:11836499, PubMed:19261748).Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909).Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698).Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211).Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604).Acts as a transcriptional activator (PubMed:20160719). Public Immunogen Range 1-350aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse;Rat 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。