英文名称 Anti-SMG6 Polyclonal Antibody 靶标 SMG6 别名 EST1-like protein A;Smg-6 homolog;hSmg5/7a;C17orf31;EST1A;KIAA0732 宿主 Rabbit 预测交叉反应 Orangutan 稀释比例 IHC 1:100-300. Gene ID 23293 Swiss Prot Q86US8 保存 Store at -20°C. Avoid freeze / thaw cycles. 蛋白分子量 37/57/160kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Nucleus 免疫原 Recombinant protein of human SMG6 亚型 IgG 纯化方法 Affinity purification 背景资料 Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)4GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629).Plays a role in nonsense-mediated mRNA decay (PubMed:18974281, PubMed:19060897, PubMed:20930030, PubMed:17053788). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:18974281, PubMed:19060897, PubMed:20930030, PubMed:17053788). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:18974281, PubMed:19060897, PubMed:20930030, PubMed:17053788). Public Immunogen Range 1-350aa 克隆类型 Polyclonal Antibody 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。