靶标 OLR1 别名 CLEC8A;LOX1;LOXIN;SCARE1;SLOX1 宿主 Rabbit 预测交叉反应 Bovine;Pig;Rabbit 稀释比例 WB 1:1000-3000. Gene ID 4973 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P78380 蛋白分子量 20/21/31kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human OLR1 亚型 IgG 纯化方法 Octanoic acid-ammonium sulfate precipitation 背景资料 Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. Public Immunogen Range 60-274aa 克隆类型 Polyclonal Antibody 交叉反应 Human Mouse Rat Predicted:Bovine Pig Rabbit 应用 WB 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。