英文名称 Anti-KCTD6 Polyclonal Antibody 靶标 KCTD6 别名 KCASH3 protein 宿主 Rabbit 预测交叉反应 ZebraFish 稀释比例 WB 1:1000-3000. Gene ID 200845 Swiss Prot Q8NC69 保存 Store at -20°C. Avoid freeze / thaw cycles. 蛋白分子量 28kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human KCTD6 亚型 IgG 纯化方法 Affinity purification 背景资料 Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887). Public Immunogen Range 1-238aa 克隆类型 Polyclonal Antibody 应用 WB 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。