靶标 AKR1C4 别名 3 alpha HSD1;3-alpha-HSD1;3-alpha-hydroxysteroid dehydrogenase type I;AK1C4_HUMAN;AKR1C4;Aldo keto reductase family 1 member C4;Aldo-keto reductase family 1 member C4;CDR;Chlordecone reductase;DD-4;DD4;Dihydrodiol dehydrogenase 4;HAKRA 宿主 Rabbit 稀释比例 WB 1:1000-3000.;IHC 1:50-200. Gene ID 1109 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P17516 蛋白分子量 37kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human AKR1C4 亚型 IgG 纯化方法 Octanoic acid-ammonium sulfate precipitation 背景资料 Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Liver specific enzyme that acts as NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain (PubMed:14672942, PubMed:10998348, PubMed:7650035, PubMed:1530633, PubMed:11158055, PubMed:10634139, PubMed:19218247).Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:14672942).Acts preferentially as a 3-alpha-hydroxysteroid dehydrogenase (HSD) with a subsidiary 3-beta-HSD activity (PubMed:14672942).Catalyzes efficiently the transformation of the potent androgen 5-alpha-dihydrotestosterone (5alpha-DHT or 17beta-hydroxy-5alpha-androstan-3-one) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:11158055, PubMed:10998348, PubMed:14672942).Catalyzes the reduction of estrone into 17beta-estradiol but with low efficiency (PubMed:14672942).Metabolizes a broad spectrum of natural and synthetic therapeutic steroid and plays an important role in metabolism of androgens, estrogens, progestereone and conjugated steroids (PubMed:10998348, PubMed:14672942, PubMed:19218247).Catalyzes the biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leading to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route (PubMed:2427522). Public Immunogen Range 3-324aa 克隆类型 Polyclonal Antibody 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。