英文名称 Anti-KITLG Polyclonal Antibody 靶标 KITLG 别名 Kit ligand;MGF;SCF;c-Kit ligand;sKITLG;MGF;SCF 宿主 Rabbit 预测交叉反应 Bovine;Chicken 稀释比例 IHC 1:100-300. Gene ID 4254 Swiss Prot P21583 保存 Store at -20°C. Avoid freeze / thaw cycles. 蛋白分子量 27/28/31kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cell membrane Cytoplasm 免疫原 Recombinant protein of human KITLG 亚型 IgG 纯化方法 Affinity purification 背景资料 Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Public Immunogen Range 1-20214aa 克隆类型 Polyclonal Antibody 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。