靶标 TFRC 别名 CD 71;CD71;CD71 antigen;IMD46;OTTHUMP00000208523;OTTHUMP00000208524;OTTHUMP00000208525;p90;sTfR;T9;TFR 1;TfR;TfR1;TFR1_HUMAN;TFRC;TR;Transferrin receptor (p90 CD71);Transferrin receptor protein 1, serum form;Trfr 宿主 Rabbit 预测交叉反应 Orangutan;Horse;Cat;Dog;Pig;Chicken 稀释比例 WB 1:1000-3000.;IHC 1:100-300. Gene ID 7037 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P02786 蛋白分子量 85kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Cell membrane Secreted 免疫原 Recombinant protein of human TFRC 亚型 IgG 纯化方法 Affinity purification 背景资料 Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738).Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738).When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738).When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738). Public Immunogen Range 101-450aa 克隆类型 Polyclonal Antibody 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。