靶标 PGAP6 别名 TMEM6 ;PGAP6 ;TMEM8A ;M83 ;Post-GPI attachment to proteins factor 6 ;GPI processing phospholipase A2 ;GPI-PLA2 ;Protein M83 ;Transmembrane protein 6 ;Transmembrane protein 8 ;Transmembrane protein 8A 宿主 Rabbit 预测交叉反应 Bovine ;Zebrafish 稀释比例 IHC 1:100-300. Gene ID 58986 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q9HCN3 蛋白分子量 85kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Cell membrane Cytoplasm 免疫原 Recombinant protein of human PGAP6 亚型 IgG 纯化方法 Affinity purification 背景资料 Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401). Public Immunogen Range 36-380aa 克隆类型 Polyclonal Antibody 交叉反应 Human ;Mouse 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。