英文名称 Anti-SHTN1 Polyclonal Antibody 靶标 SHTN1 别名 Shootin-1;Shootin1;KIAA1598 宿主 Rabbit 稀释比例 WB 1:1000-3000. Gene ID 57698 Swiss Prot A0MZ66 保存 Store at -20°C. Avoid freeze / thaw cycles. 蛋白分子量 24/53/56/63/65/68/72/74kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human SHTN1 亚型 IgG 纯化方法 Octanoic acid-ammonium sulfate precipitation 背景资料 Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. Public Immunogen Range 1-125aa 克隆类型 Polyclonal Antibody 应用 WB 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。