靶标 ARG1 别名 arginase-1 宿主 Rabbit 预测交叉反应 Bovine;A.thaliana;Rabbit;Pig 稀释比例 WB 1:1000-3000. Gene ID 383 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P05089 蛋白分子量 25/35kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Nucleus 免疫原 Recombinant protein of human ARG1 亚型 IgG 纯化方法 Affinity purification 背景资料 Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion. In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity). In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure. Public Immunogen Range 1-323aa 克隆类型 Polyclonal Antibody 应用 WB 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。