靶标 ABL1 别名 Abelson murine leukemia viral oncogene homolog 1;Abelson tyrosine protein kinase 1;Abl 1;ABL;ABL proto oncogene 1 non receptor tyrosine kinase;ABL1;ABL1_HUMAN;bcr/abl;bcr/c abl oncogene protein;c ABL;c abl oncogene 1 non receptor tyrosine kinase;c abl oncogene 1 receptor tyrosine kinase;c ABL1;JTK7;p150;Proto oncogene tyrosine protein kinase ABL1;Proto-oncogene c-Abl 宿主 Rabbit 稀释比例 IHC 1:100-300. Gene ID 25 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P00519 蛋白分子量 123/125kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Cytoplasm Nucleus 免疫原 A synthetic peptide of human ABL1 亚型 IgG 纯化方法 Affinity purification 背景资料 This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. Public Immunogen Range 195-245/1130aa 克隆类型 Polyclonal Antibody 交叉反应 Human 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。