英文名称 Anti-RAPGEF3 Polyclonal Antibody 靶标 RAPGEF3 别名 EPAC 1;cAMP-GEFI;CGEF1;EPAC;EPAC1; 宿主 Rabbit 稀释比例 WB 1:1000-3000;IHC 1:100-300. Gene ID 10411 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot O95398 蛋白分子量 66/99/104kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 A synthetic peptide of human RAPGEF3 亚型 IgG 纯化方法 Affinity purification 背景资料 Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. Public Immunogen Range 785-835/923aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse;Rat 应用 WB;IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。