靶标 DAAM2 别名 DAAM2; DAAM2_HUMAN; Disheveled-associated activator of morphogenesis 2; dishevelled associated activator of morphogenesis 2; dJ90A20A.1; KIAA0381; MGC90515; RP1 278E11.1 宿主 Rabbit 预测交叉反应 Chicken 稀释比例 IHC 1:100-300. Gene ID 23500 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q6DCB0 蛋白分子量 15kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human DAAM2 亚型 IgG 纯化方法 Affinity purification 背景资料 Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1. Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. Public Immunogen Range 1-133aa 克隆类型 Polyclonal Antibody 交叉反应 Human Mouse Predicted:Chicken 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。