靶标 GNAI1 别名 Adenylate cyclase inhibiting G alpha protein; Adenylate cyclase inhibitory protein; Adenylate cyclase-inhibiting G alpha protein; G protein alpha inhibiting 1; G protein alpha inhibiting activity polypeptide 1; Gi; Gi inhibitory G protein; Gi1 protein alpha subunit; GNAI 1; GNAI1; GNAI1_HUMAN; Guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 1; Guanine nucleotide binding protein G(i) alpha 1 subunit; Guanine nucleotide-binding protein G(i) subunit alpha-1; OTTHUMP00000161319; OTTHUMP00000208047 宿主 Rabbit 预测交叉反应 Bovine;Orangutan;Chicken 稀释比例 WB 1:1000-3000. Gene ID 2770 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P63096 蛋白分子量 35/40kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human GNAI1 亚型 IgG 纯化方法 Affinity purification 背景资料 Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis. Required for cortical dynein-dynactin complex recruitment during metaphase. Public Immunogen Range 1-355aa 克隆类型 Polyclonal Antibody 交叉反应 Human Mouse Rat Predicted:Bovine Orangutan Chicken 应用 WB 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。