靶标 PTPN22 别名 LYP;LYP1;LYP2;PEP;PTPN22.5;PTPN22.6;PTPN8 宿主 Rabbit 稀释比例 WB 1:1000-3000.;IHC 1:100-300. Gene ID 26191 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q9Y2R2 蛋白分子量 21/75/85/92kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human PTPN22 亚型 IgG 纯化方法 Affinity purification 背景资料 Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy. Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). Public Immunogen Range 1-180aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse 应用 WB;IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。