Solarbio K111927P Anti-PRKAG1 Polyclonal Antibody
- 销售价:
- ¥768.00
- 市场价:
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¥960.00 - 编号:
- 202302241034307
- 货号:
- K111927P-50ul
-
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商品介绍
靶标
PRKAG1
别名
5' AMP activated protein kinase gamma 1 subunit;5' AMP activated protein kinase subunit gamma 1;5''-AMP-activated protein kinase subunit gamma-1;AAKG1_HUMAN;AMP activated protein kinase noncatalytic gamma 1 subunit;AMPK gamma 1 chain;AMPK gamma1;AMPK subunit gamma-1;AMPKg;MGC8666;PRKAG 1;PRKAG1;Protein kinase AMP activated gamma 1 non catalytic subunit;protein kinase, AMP-activated, noncatalytic gamma-1
宿主
Rabbit
预测交叉反应
Bovine;Pig
稀释比例
IHC 1:100-300.
Gene ID
5571
保存
Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot
P54619
蛋白分子量
34/38/39kDa
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4.
亚细胞定位
Cytoplasm Nucleus Cell membrane
免疫原
Recombinant protein of human PRKAG1
亚型
IgG
纯化方法
Affinity purification
背景资料
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Public Immunogen Range
1-332aa
克隆类型
Polyclonal Antibody
交叉反应
Human;Mouse;Rat
应用
IHC
规格
50ul 100ul
使用前请离心。如有问题请及时联系我们。
商品参数
商品介绍 | |
---|---|
单位 | 支 |
品牌 | Solarbio |
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