产品简介

基因名 GNAS

英文全称 GNAS complex locus

别称 GNAS1;GNASXL;GPSA;NESP;NESP55;SCG6;SgVI

中文名称 GNAS复合体基因座

Uniprot O95467

GeneID 2778

交叉反应(推测) Human Mouse Rat (Bovine Fruit fly)

氨基酸大小 28kDa

表达氨基酸 1-245aa

Background This locus has a highly complex imprinted expression pattern.It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons.Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression.An antisense transcript is produced from an overlapping locus on the opposite strand.One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region.In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex.Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses.Multiple transcript variants encoding different isoforms have been found for this gene.Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

Application Immunology research

Derived from E.coli

Purification NI-NTA affinity purification

Formulation Lyophilized from a 0.2 μm filtered solution of Urea, Tris-HCl, PH8.0.

Shipping The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.

Storage Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years.

Reconstitution Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Purity Purity≥85% as determined by reducing SDS-PAGE.

Endotoxin /

Bioactive Not tested.

Tag information With a 6His tag at the N-terminus.

单位 支

规格 10ug 50ug 100ug 1mg

备注：

以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。